Insulin is a kinetic but not a thermodynamic inhibitor of amylin aggregation
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چکیده
منابع مشابه
Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: implications for the pathogenesis and treatment of Alzheimer disease.
The apolipoprotein E4 (APOE4) allele is associated with an early age of onset of the nonfamilial form of Alzheimer disease (AD) and with increased beta protein amyloid deposition in the brain. These two observations may both arise from an effect of the apoE family of proteins on the rate of in vivo amyloidogenesis. We report here that apoE3, the common apoE isoform, is an in vitro amyloid nucle...
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Novel insights into amylin aggregation
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ژورنال
عنوان ژورنال: FEBS Journal
سال: 2009
ISSN: 1742-464X,1742-4658
DOI: 10.1111/j.1742-4658.2009.07061.x